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KMID : 0377619720220020201
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Korean Jungang Medical Journal
1972 Volume.22 No. 2 p.201 ~ p.204
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Immunologic Significance of the Uptake of Protein Antigens by Thoracic Duct Lymphocytes
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Abstract
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In this study male Sprague-Dawley rats weighing 400 to 500 grams were used.
The assessment of the interaction between the thoracic duct lymphocytes and ferritin-1131
under in vitro condition; that is, the effects of the dose, endotoxin and poly A:U on in vitro uptake of antigen were observed.
The results were as follows;
1. The relative uptake was the greatest with 1mg of ferritin per culture, reaching up to 2% of the total ferritin in the medium.
2. When endotoxin was added, there was a general reduction, but the reduction was not influenced.
3. The addition of poly A:U caused a more severe inhibition of uptake. Up to 80% inhibition was observed with 25,μg of poly A:U, whereas progressively smaller reduction was seen with decreasing amounts of poly A:U added.
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KEYWORD
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